Department of Biochemistry and Biophysics

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  • Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion 2021-09-08 The pyruvate dehydrogenase complex is a multienzyme complex of megadalton size that converts pyruvate into acetyl-coenzyme A, thereby linking glycolysis to the citric acid cycle and to the biosynthesis of fatty acids. In a new study from DBB, scientists for the first time, reveal how the lipoyl domains interact with the core of a pyruvate dehydrogenase complex, to insert substrate into the active site. The study is published in Nature Communications.
  • AlphaFold 2 and SciLifeLab: advancing structural biology beyond protein folding 2021-08-27 That artificial intelligence has the potential to aid researchers and speed up scientific processes should come as no surprise by now. The speed of things, however, baffle even the most experienced. The AlphaFold 2 tool has been said to have the possibility of sparking a medical revolution and transforming structural biology, but is it really that life-changing and are the predictions accurate enough?
  • Eva Hedlund lab takes the ALS Ice Bucket Challenge for Stockholms University 2021-07-02
  • Congratulations Anna-Lena Ström, Teacher of the Year 2021! 2021-06-03 The 2021 Laureates of the Year are Matilda Baraibar, Department of Economic History and International Relations, Sören Holst, Physics, Adam Jacobsson, Department of Economics, Christophe Premat, Department of Romance and Classical Sciences and Anna-Lena Ström, Department of Biochemistry and Biophysics.
  • Revealing how the cell uptakes sugar 2021-05-06 Over half of our drugs impact proteins found on the cell membrane. These include the membrane proteins that regulate uptake of sugar by cells. Wallenberg Scholar David Drew is breaking new ground by adding to our understanding of the structure and function of transport proteins.
  • Stockholm University receives four ERC Advanced Grants 2021-04-23 Four researchers at Stockholm University including Christian Broberger at DBB are awarded prestigious ERC Advanced Grants. Their areas of research are within theater studies, neurochemistry and physics.